Perfusion Recellularization

Perfusion recellularization begins with organ scaffolds created by perfusion decellularization. These scaffolds are capable of receiving and incorporating a variety of cell types, depending on the organ scaffold utilized. Perfusion decellularization enables organ scaffolds to retain their native vasculature and so cells are introduced through existing vascular pathways.

Miromatrix has developed an automated system that mimics natural vascular mechanics as cells grow and mature inside the recellularizing organs. Moreover, as cell type discovery continues to grow, the fact that scaffolds created with this technology are of a natural biological design make them an ideal template to support the growth and differentiation of stem cells into functional tissues, organs and bioidentical test beds. As specific cells are introduced via perfusion they migrate to the appropriate microenvironment. The organs are then grown and are matured in bioreactors under normal physiological conditions.

The resulting organs can be transplanted utilizing the same techniques as current organ transplantation. the recellularization of each organ poses its own set of unique challenges. Our organ teams continue to make significant strides in bringing Recellularization organ therapies to the market.

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Perfusion recellularization can be applied to multiple organ models.  Our organ development teams are leading the way in bringing recellularized livers, hearts and kidneys to the market.